Edit RNA

Edit RNA!

Nature 542, 494-497 (23 February 2017)

Editing and methylation at a single site by functionally interdependent activities

Mary Anne T. Rubio, Kirk W. Gaston, Katherine M. McKenney, Ian M.C. Fleming, Zdenek Paris, Patrick A. Limbach and Juan D. Alfonzo




Nature 542, 420-421 (23 February 2017)

Molecular biology: RNA editing packs a one-two punch

William T. Yewdell & Jayanta Chaudhuri



Graphic Design Acknowledgments: Juan Alfonzo, Mary Anne Rubio, Chris Trotta and Craig Foster







"The scientist does not study nature because it is useful; 
he studies it because he delights in it, and he delights in it because it is beautiful. 
If nature were not beautiful, it would not be worth knowing, 
and if nature were not worth knowing, life would not be worth living." 
-Jules Henri Poincare (1854-1912); French mathematician.

The Alfonzolab &  "Thing":  Cuatro de Mayo, 2013





OUR INTERESTS:   RNA, RNA and RNA!

WHO: trypanosomes, yeast, mammals, archaebacteria

WHAT: tRNA modification, tRNA editing, tRNA   transport, tRNA maturation

WHEN: preferably all the time

HOW:  biochemistry, microbiology, genetics, bioinformatics, structural biology

WHERE: Dept. of Microbiology;  The Center for RNA Biology 









tRNA Editing and Modification...location, location, location!

 

 

 

 

 

Two major mechanisms import tRNAs to mitochondria: (Alfonzo & Soll 2009)

 

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Alfonzolab: March 2012